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Title: Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles
Authors: Li, Yan
Widodo, Jasmine
Lim, Sierin
Ooi, Chui Ping
Keywords: DRNTU::Engineering::Chemical engineering
Issue Date: 2011
Source: Li, Y., Widodo, J., Lim, S., & Ooi, C. P. (2012). Synthesis and cytocompatibility of manganese (II) and iron (III) substituted hydroxyapatite nanoparticles. Journal of Materials Science, 47(2), 754-763.
Series/Report no.: Journal of materials science
Abstract: Manganese (II) and iron (III) substituted hydroxyapatite (HA, Ca10(PO4)6(OH)2) nanoparticles were synthesized using wet chemical method. All samples were single-phase, non-stoichiometric and B-type carbonated hydroxyapatite. Compared with pure HA, Mn2+ substituted (MnHA) and Fe3+ doped HA (FeHA) did not demonstrate significant structure deviation. Since ion exchange mechanism was applied for the synthesis process, the morphology and particle size were not significantly affected: all samples were elongated spheroids of around 70 nm. The presence of Fe and Mn was confirmed by energy dispersive X-ray spectroscopy (EDX) while the concentrations were quantified by inductively coupled plasma (ICP). Fe3+ ions were more active than Mn2+ ions in replacing Ca2+ ions in HA lattice structure. The magnetic property of HA was modified by substitution with Fe. The Fe5 (Feadded/Caadded = 5% by molar ratio) was paramagnetic while pure HA was diamagnetic. Results of extraction assay from cells cultured in extracted medium for 72 h suggested that both MnHA and FeHA were non-cytotoxic to osteoblast cells. Meanwhile, the presence of Fe3+ ions in HA demonstrated significant positive effect on osteoblast cells, where the cell number on Fe5 pellets was twice that of pure HA and MnHA samples.
DOI: 10.1007/s10853-011-5851-7
Rights: © 2011 Springer Science+Business Media, LLC.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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