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dc.contributor.authorHillard, Elizabeth A.en
dc.contributor.authorTan, Kelvin Yong Lengen
dc.contributor.authorPigeon, Pascalen
dc.contributor.authorTop, Sidenen
dc.contributor.authorLabbé, Ericen
dc.contributor.authorBuriez, Olivieren
dc.contributor.authorVessières, Anneen
dc.contributor.authorAmatore, Christianen
dc.contributor.authorLeong, Weng Keeen
dc.contributor.authorJaouen, Gérarden
dc.identifier.citationTan, K. Y. L., Pigeon, P., Top, S., Labbé, E., Buriez, O., Hillard, E. A., et al. (2012). Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells. Dalton Transactions, 41(25), 7537-7549.en
dc.description.abstractThe synthesis and anti-tumoral properties of a series of compounds possessing a ferrocenyl group tethered to a catechol via a conjugated system is presented. On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC50 values ranging from 0.48–1.21 μM) than their corresponding phenolic analogues (0.57–12.7 μM), with the highest activity found for species incorporating the [3]ferrocenophane motif. On the electrochemical timescale, phenolic compounds appear to oxidize to the quinone methide, while catechol moieties form the o-quinone by a similar mechanism. Chemical oxidation of selected compounds with Ag2O confirms this interpretation and demonstrates the probable involvement of such oxidative metabolites in the in vitro activity of these species.en
dc.relation.ispartofseriesDalton transactionsen
dc.rights© 2012 The Royal Society of Chemistry.en
dc.titleFerrocenyl catechols : synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cellsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
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