Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/96608
Title: Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe
Authors: Yuen, Clement
Liu, Quan
Keywords: DRNTU::Science::Chemistry::Biochemistry
Issue Date: 2013
Source: Yuen, C., & Liu, Q. (2013). Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe. Journal of biophotonics, 7(9), 683-689.
Series/Report no.: Journal of biophotonics
Abstract: We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance.
URI: https://hdl.handle.net/10356/96608
http://hdl.handle.net/10220/18057
ISSN: 1864-063X
DOI: 10.1002/jbio.201300006
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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