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Title: Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography
Authors: Wang, Ren-Qi
Ong, Teng-Teng
Ng, Siu-Choon
Keywords: DRNTU::Engineering::Chemical engineering
Issue Date: 2011
Source: Wang, R.-Q., Ong, T.-T., & Ng, S.-C. (2012). Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography. Journal of Chromatography A, 1224, 97-103.
Series/Report no.: Journal of chromatography A
Abstract: Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives. The electrostatic force between the analytes and the cationic moiety on β-CD derivative was found to be important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. It was also found that the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions.
ISSN: 0021-9673
DOI: 10.1016/j.chroma.2011.12.053
Rights: © 2011 Elsevier B.V.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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