Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97159
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dc.contributor.authorTay, Felicia P. L.en
dc.contributor.authorHuang, Meien
dc.contributor.authorWang, Lien
dc.contributor.authorYamada, Yoshiyukien
dc.contributor.authorLiu, Ding Xiangen
dc.date.accessioned2013-07-17T07:22:30Zen
dc.date.accessioned2019-12-06T19:39:30Z-
dc.date.available2013-07-17T07:22:30Zen
dc.date.available2019-12-06T19:39:30Z-
dc.date.copyright2012en
dc.date.issued2012en
dc.identifier.citationTay, F. P. L., Huang, M., Wang, L., Yamada, Y., & Liu, D. X. (2012). Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection. Virology, 433(2), 421-430.en
dc.identifier.issn0042-6822en
dc.identifier.urihttps://hdl.handle.net/10356/97159-
dc.description.abstractIn previous studies, the Beaudette strain of coronavirus infectious bronchitis virus (IBV) was adapted from chicken embryo to Vero, a monkey kidney cell line, by serial propagation for 65 passages. To characterize the susceptibility of other human and animal cells to IBV, 15 human and animal cell lines were infected with the Vero-adapted IBV and productive infection was observed in four human cell lines: H1299, HepG2, Hep3B and Huh7. In other cell lines, the virus cannot be propagated beyond passage 5. Interestingly, cellular furin abundance in five human cell lines was shown to be strongly correlated with productive IBV infection. Cleavage of IBV spike protein by furin may contribute to the productive IBV infection in these cells. The findings that IBV could productively infect multiple human and animal cells of diverse tissue and organ origins would provide a useful system for studying the pathogenesis of coronavirus.en
dc.language.isoenen
dc.relation.ispartofseriesVirologyen
dc.rights© 2012 Elsevier Inc.en
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleCharacterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infectionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1016/j.virol.2012.08.037en
item.fulltextNo Fulltext-
item.grantfulltextnone-
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