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Title: Pluronic triblock copolymer encapsulated gold nanorods as biocompatible localized plasmon resonance-enhanced scattering probes for dark-field imaging of cancer cells
Authors: Dinish, U. S.
Goh, Douglas
Gong, Tianxun
Maiti, Kaustabh Kumar
Fu, Chit Yaw
Yong, Ken-Tye
Olivo, Malini
Issue Date: 2012
Source: Goh, D., Gong, T., Dinish, U. S., Maiti, K. K., Fu, C. Y., Yong, K.-T., et al. (2012). Pluronic Triblock Copolymer Encapsulated Gold Nanorods as Biocompatible Localized Plasmon Resonance-Enhanced Scattering Probes for Dark-Field Imaging of Cancer Cells. Plasmonics, 7(4), 595-601.
Series/Report no.: Plasmonics
Abstract: Gold nanorods (GNR) are synthesized using cetylmethylammonium bromide (CTAB) surfactants which function as structure-directing agents. However, CTAB forms a tightly bound cationic bilayer on GNR surface with the cationic trimethylammonium head group exposed to the aqueous media, which is known to be highly toxic in vitro and in vivo. Pluronic is a non-ionic triblock polymer, which can associate with CTAB and form stable CTAB–polymer complexes due to hydrophobic interactions. In this work, two types of Pluronic triblock copolymers were used to encapsulate GNR to reduce their cytotoxicity and improve colloidal and optical stability for biological applications. These formulations were characterized by UV–vis absorption spectra analysis, transmission electron microscopy, cell viability studies, differential interference contrast microscopy and dark-field imaging.
ISSN: 1557-1955
DOI: 10.1007/s11468-012-9347-3
Schools: School of Electrical and Electronic Engineering 
Rights: © 2012 Springer Science+Business Media, LLC.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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