Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97244
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dc.contributor.authorYang, Chien
dc.contributor.authorXu, Chunxiangen
dc.contributor.authorWang, Xuemeien
dc.contributor.authorHu, Xiaoen
dc.date.accessioned2013-06-27T01:41:11Zen
dc.date.accessioned2019-12-06T19:40:33Z-
dc.date.available2013-06-27T01:41:11Zen
dc.date.available2019-12-06T19:40:33Z-
dc.date.copyright2012en
dc.date.issued2012en
dc.identifier.citationYang, C., Xu, C., Wang, X., & Hu, X. (2012). Quantum-dot-based biosensor for simultaneous detection of biomarker and therapeutic drug: first steps toward an assay for quantitative pharmacology. Analyst, 137(5), 1205-1209.en
dc.identifier.issn0003-2654en
dc.identifier.urihttps://hdl.handle.net/10356/97244-
dc.description.abstractQuantitative pharmacology (QP) is often used to study the recommended dose of a drug. Using colorectal cancer as a model, the relationship between exposure (cetuximab, C225, therapeutic drug of colorectal cancer) and the biomarker response (carcinoembryonic antigen, CEA, biomarker of colorectal cancer) is the core for the QP of C225. Thus, simultaneous detection of CEA and C225 is the first step towards an assay for the QP of C225. We developed a quantum dot (QD)-based multi-analyte biosensor for the simultaneous determination of CEA and the corresponding therapeutic drug C225. The assay is based on the competition between a quantum-dots-labeled glycans and target glycans using lectins as the recognition element. The dual-analytic biosensor detected CEA and C225 in the range from 1 ng mL−1 to 400 μg mL−1 by stripping voltammetry. The biosensor developed here for the simultaneous detection of the biomarkers and therapeutic drugs is expected to develop as a potential technique for quantitative pharmacology.en
dc.language.isoenen
dc.relation.ispartofseriesAnalysten
dc.rights© 2012 The Royal Society of Chemistry.en
dc.titleQuantum-dot-based biosensor for simultaneous detection of biomarker and therapeutic drug : first steps toward an assay for quantitative pharmacologyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.identifier.doi10.1039/c2an15894aen
item.grantfulltextnone-
item.fulltextNo Fulltext-
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