Selective catalytic sp3 C–O bond cleavage with C–N bond formation in 3-alkoxy-1-propanols

Abstract

The ruthenium catalyzed selective sp3 C–O cleavage with amide formation was reported in reactions of 3-alkoxy-1-propanol derivatives and amines. The cleavage only occurs at the C3–O position even with 3-benzyloxy-1-propanol. Based on the experimental results, O-bound and C-bound Ru enolate complexes were proposed as key intermediates for the unique selective sp3 C–O bond cleavage in 3-alkoxy-1-propanols.