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https://hdl.handle.net/10356/97399
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mei, Ye | en |
dc.contributor.author | Zhang, Dawei | en |
dc.contributor.author | Xu, Zhijun | en |
dc.contributor.author | Lazim, Raudah | en |
dc.date.accessioned | 2013-06-27T04:43:23Z | en |
dc.date.accessioned | 2019-12-06T19:42:13Z | - |
dc.date.available | 2013-06-27T04:43:23Z | en |
dc.date.available | 2019-12-06T19:42:13Z | - |
dc.date.copyright | 2012 | en |
dc.date.issued | 2012 | en |
dc.identifier.citation | Xu, Z., Lazim, R., Mei, Y., & Zhang, D. (2012). Stability of the β-structure in prion protein: A molecular dynamics study based on polarized force field. Chemical Physics Letters, 539-540, 239-244. | en |
dc.identifier.issn | 0009-2614 | en |
dc.identifier.uri | https://hdl.handle.net/10356/97399 | - |
dc.description.abstract | Conformational changes of the antiparallel β-sheet in normal cellular prion protein (PrPC) of rat, bovine, and human are investigated by molecular dynamics simulations in both neutral and acidic environment. Using a recently developed simulation method based on an on-the-fly polarized protein-specific charge (PPC) update scheme during the simulation process, we evaluate and compare the cross-species performances of the β-sheet during the early stage transition from the PrPC to its mutant configuration. Through this study, we observe the growth of the β-sheet structure in all species studied with the extent of elongation in β-sheet being different across the three species. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Chemical physics letters | en |
dc.rights | © 2012 Elsevier B.V. | en |
dc.title | Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field | en |
dc.type | Journal Article | en |
dc.contributor.school | School of Physical and Mathematical Sciences | en |
dc.identifier.doi | 10.1016/j.cplett.2012.05.025 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | SPMS Journal Articles |
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