Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97423
Title: Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
Authors: Prasad, Paras N.
Liu, Liwei
Yong, Ken-Tye
Roy, Indrajit
Law, Wing-Cheung
Ye, Ling
Liu, Jianwei
Liu, Jing
Kumar, Rajiv
Zhang, Xihe
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Liu, L., Yong, K.-T., Roy, I., Law, W.-C., Ye, L., Liu, J., et al. (2012). Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies. Theranostics, 2(7), 705-713.
Series/Report no.: Theranostics
Abstract: Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice.
URI: https://hdl.handle.net/10356/97423
http://hdl.handle.net/10220/11854
ISSN: 1838-7640
DOI: 10.7150/thno.3456
Rights: © 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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