Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97481
Title: Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications
Authors: May, Jasmine L.
Swihart, Mark T.
Prasad, Paras N.
Erogbogbo, Folarin
Chang, Ching-Wen
Liu, Liwei
Kumar, Rajiv
Law, Wing-Cheung
Ding, Hong
Yong, Ken-Tye
Roy, Indrajit
Sheshadri, Mukund
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Erogbogbo, F., Chang, C.-W., May, J. L., Liu, L., Kumar, R., Law, W.-C., et al. (2012). Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications. Nanoscale, 4(17), 5483-5489.
Series/Report no.: Nanoscale
Abstract: Luminescent imaging agents and MRI contrast agents are desirable components in the rational design of multifunctional nanoconstructs for biological imaging applications. Luminescent biocompatible silicon quantum dots (SiQDs) and gadolinium chelates can be applied for fluorescence microscopy and MRI, respectively. Here, we report the first synthesis of a nanocomplex incorporating SiQDs and gadolinium ions (Gd3+) for biological applications. The nanoconstruct is composed of a PEGylated micelle, with hydrophobic SiQDs in its core, covalently bound to DOTA-chelated Gd3+. Dynamic light scattering reveals a radius of 85 nm for these nanoconstructs, which is consistent with the electron microscopy results depicting radii ranging from 25 to 60 nm. Cellular uptake of the probes verified that they maintain their optical properties within the intracellular environment. The magnetic resonance relaxivity of the nanoconstruct was 2.4 mM−1 s−1 (in terms of Gd3+ concentration), calculated to be around 6000 mM−1 s−1 per nanoconstruct. These desirable optical and relaxivity properties of the newly developed probe open the door for use of SiQDs in future multimodal applications such as tumour imaging.
URI: https://hdl.handle.net/10356/97481
http://hdl.handle.net/10220/10724
ISSN: 2040-3364
DOI: 10.1039/c2nr31002c
Rights: © 2012 The Royal Society of Chemistry.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

SCOPUSTM   
Citations

58
checked on Sep 4, 2020

WEB OF SCIENCETM
Citations

56
checked on Oct 19, 2020

Page view(s)

438
checked on Oct 21, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.