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Title: Enantioselective intramolecular formal [2 + 4] annulation of acrylates and α,β-unsaturated imines catalyzed by amino acid derived phosphines
Authors: Jin, Zhichao
Yang, Ruojie
Du, Yu
Tiwari, Bhoopendra
Ganguly, Rakesh
Chi, Robin Yonggui
Issue Date: 2012
Source: Jin, Z., Yang, R., Du, Y., Tiwari, B., Ganguly, R., & Chi, Y. R. (2012). Enantioselective Intramolecular Formal [2 + 4] Annulation of Acrylates and α,β-Unsaturated Imines Catalyzed by Amino Acid Derived Phosphines. Organic Letters, 14(12), 3226-3229.
Series/Report no.: Organic letters
Abstract: The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures.
ISSN: 1523-7060
DOI: 10.1021/ol3013588
Rights: © 2012 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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