Development of nanomaterials for SALDI-MS analysis in forensics

Abstract

Within the last decade, the escalation of research output in the field of nanotechnology has spurred the development of new nanomaterials for use as assisting agents in surface assisted laser desorption ionization mass spectrometry (SALDI-MS). Specifically modified nanomaterials, coupled with mass spectrometry, have improved the detection sensitivity, specificity, flexibility and reproducibility of SALDI-MS analysis. The technological advancement of LDI-MS has in turn, propelled the use of the analytical technique in the field of forensics. In this report, the various roles and applications of metal-, silicon- and carbon-based nanostructured materials as SALDI matrices in the analysis of forensic samples are described. The advantages of SALDI-MS as an analytical tool for forensic sample analysis are also discussed.