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https://hdl.handle.net/10356/97571| Title: | Highly enantioselective addition of enals to isatin-derived ketimines catalyzed by N-heterocyclic carbenes : synthesis of spirocyclic γ-lactams | Authors: | Lv, Hui Tiwari, Bhoopendra Mo, Junming Xing, Chong Chi, Robin Yonggui |
Issue Date: | 2012 | Source: | Lv, H., Tiwari, B., Mo, J., Xing, C., & Chi, Y. R. (2012). Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams. Organic Letters, 14(21), 5412-5415. | Series/Report no.: | Organic letters | Abstract: | An N-heterocyclic carbene (NHC)-catalyzed annulation reaction of isatin N-Boc ketimines and enals is developed for the synthesis of spirocyclic oxindole-γ-lactams bearing one quaternary chiral center in good yields and excellent stereoselectivities (up to >20:1 dr and 99% ee). | URI: | https://hdl.handle.net/10356/97571 http://hdl.handle.net/10220/10587 |
ISSN: | 1523-7060 | DOI: | 10.1021/ol302475g | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2012 American Chemical Society. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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