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|Title:||Highly enantioselective addition of enals to isatin-derived ketimines catalyzed by N-heterocyclic carbenes : synthesis of spirocyclic γ-lactams||Authors:||Lv, Hui
Chi, Robin Yonggui
|Issue Date:||2012||Source:||Lv, H., Tiwari, B., Mo, J., Xing, C., & Chi, Y. R. (2012). Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams. Organic Letters, 14(21), 5412-5415.||Series/Report no.:||Organic letters||Abstract:||An N-heterocyclic carbene (NHC)-catalyzed annulation reaction of isatin N-Boc ketimines and enals is developed for the synthesis of spirocyclic oxindole-γ-lactams bearing one quaternary chiral center in good yields and excellent stereoselectivities (up to >20:1 dr and 99% ee).||URI:||https://hdl.handle.net/10356/97571
|ISSN:||1523-7060||DOI:||10.1021/ol302475g||Rights:||© 2012 American Chemical Society.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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