Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97571
Title: Highly enantioselective addition of enals to isatin-derived ketimines catalyzed by N-heterocyclic carbenes : synthesis of spirocyclic γ-lactams
Authors: Lv, Hui
Tiwari, Bhoopendra
Mo, Junming
Xing, Chong
Chi, Robin Yonggui
Issue Date: 2012
Source: Lv, H., Tiwari, B., Mo, J., Xing, C., & Chi, Y. R. (2012). Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams. Organic Letters, 14(21), 5412-5415.
Series/Report no.: Organic letters
Abstract: An N-heterocyclic carbene (NHC)-catalyzed annulation reaction of isatin N-Boc ketimines and enals is developed for the synthesis of spirocyclic oxindole-γ-lactams bearing one quaternary chiral center in good yields and excellent stereoselectivities (up to >20:1 dr and 99% ee).
URI: https://hdl.handle.net/10356/97571
http://hdl.handle.net/10220/10587
ISSN: 1523-7060
DOI: 10.1021/ol302475g
Rights: © 2012 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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