Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97592
Title: Silver nanocube-enhanced far-red/near-infrared fluorescence of conjugated polyelectrolyte for cellular imaging
Authors: Gurzadyan, Gagik G.
Liang, Jing
Li, Kai
Lu, Xianmao
Liu, Bin
Keywords: DRNTU::Science::Physics
Issue Date: 2012
Series/Report no.: Langmuir
Abstract: We present the study of silver nanocube (Ag NC)-enhanced fluorescence of a cationic conjugated polyelectrolyte (CPE) for far-red/near-infrared fluorescence cell imaging. Layer-by-layer self-assembly of polyelectrolytes on 78 nm Ag NCs is used to control CPE–metal distance and its effect on CPE fluorescence. The highest fluorescence enhancement factor (FEF) is obtained for Ag NCs with two bilayers, corresponding to a CPE–metal spacer thickness of 6 nm. At the optimal excitation wavelength, the FEF is 13.8 with respect to the control silica nanoparticles (NPs). The fluorescent NPs are further used for cellular imaging studies. The CPE-loaded Ag NCs with two bilayers exhibit excellent image contrast, superior to the control of CPE–silica NP at a similar uptake efficiency. The viability test indicates low cytotoxicity of the CPE-loaded Ag NCs, rendering them as promising cell imaging agents.
URI: https://hdl.handle.net/10356/97592
http://hdl.handle.net/10220/11355
DOI: 10.1021/la302511e
Rights: © 2012 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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