Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97674
Title: PEGylated phospholipid Micelle-encapsulated near-infrared PbS quantum dots for in vitro and in vivo bioimaging
Authors: Reynolds, Jessica L.
Hu, Rui
Law, Wing-Cheung
Lin, Guimiao
Ye, Ling
Liu, Jianwei
Liu, Jing
Yong, Ken-Tye
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Hu, R., Law, W.-C., Lin, G., Ye, L., Liu, J., Liu, J., et al. (2012). PEGylated Phospholipid Micelle-Encapsulated Near-Infrared PbS Quantum Dots for in vitro and in vivo Bioimaging. Theranostics, 2(7), 723-733.
Series/Report no.: Theranostics
Abstract: Surface modification and functionalization of bioconjugated quantum dots (QDs) has drawn great attention for the past few years due to their wide applications in biomedical research. In this contribution, we demonstrate the use of PEGylated phospholipid micelles to encapsulate near infrared emitting ultra-small lead sulfide (PbS) QDs for in vitro and in vivo imaging. The cytotoxicity of the micelle-encapsulated QDs formulation was evaluated using MTS assay and histological analysis studies. We have found that upon encapsulating the QDs with phospholipid micelle, the toxicity of the PbS QDs is reduced, from which we envision that the PEGylated phospholipid micelle-encapsulated PbS QDs formulation can be used as theranostics probes for some selected applications in cell imaging and small animals study.
URI: https://hdl.handle.net/10356/97674
http://hdl.handle.net/10220/11856
ISSN: 1838-7640
DOI: 10.7150/thno.4275
Rights: © 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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