Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97780
Title: Matricellular proteins : a sticky affair with cancers
Authors: Chong, Han Chung
Tan, Chek Kun
Huang, Royston-Luke
Tan, Nguan Soon
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Source: Chong, H. C., Tan, C. K., Huang, R.-L., & Tan, N. S. (2012). Matricellular proteins: a sticky affair with cancers. Journal of oncology, 2012, 1-17.
Series/Report no.: Journal of oncology
Abstract: The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a variety of molecular mechanisms. Matricellular proteins provide signals that support tumorigenic activities characteristic of the metastastic cascade such as epithelial-to-mesenchymal (EMT) transition, angiogenesis, tumor cell motility, proliferation, invasion, evasion from immune surveillance, and survival of anoikis. Herein, we review the current understanding of the following matricellular proteins and highlight their pivotal and multifacted roles in metastatic progression: angiopoietin-like protein 4 (ANGPTL4), CCN family members cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) and CCN6, osteopontin (OPN), secreted protein acidic and rich in cysteine (SPARC), tenascin C (TNC), and thrombospondin-1 and -2 (TSP1, TSP2). Insights into the signaling mechanisms resulting from the interaction of these matricellular proteins and their respective molecular partner(s), as well as their subsequent contribution to tumor metastasis, are discussed. In addition, emerging evidences of their promising potential as therapeutic options and/or targets in the treatment of cancer are also highlighted.
URI: https://hdl.handle.net/10356/97780
http://hdl.handle.net/10220/17102
DOI: 10.1155/2012/351089
Rights: © 2012 The Authors. This paper was published in Journal of Oncology and is made available as an electronic reprint (preprint) with permission of the authors. The paper can be found at the following official DOI: [http://dx.doi.org/10.1155/2012/351089]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Files in This Item:
File Description SizeFormat 
Matricellular Proteins A Sticky Affair with Cancers.pdf2.26 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 50

87
Updated on Feb 26, 2021

PublonsTM
Citations 50

90
Updated on Feb 27, 2021

Page view(s) 50

354
Updated on Mar 5, 2021

Download(s) 20

256
Updated on Mar 5, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.