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Title: Preparation of quantum dot/drug nanoparticle formulations for traceable targeted delivery and therapy
Authors: Swihart, Mark T.
Mahajan, Supriya D.
Reynolds, Jessica L.
Yong, Ken-Tye
Wang, Yucheng
Roy, Indrajit
Rui, Hu
Law, Wing-Cheung
Kwak, Sang Kyu
Ye, Ling
Liu, Jianwei
Issue Date: 2012
Source: Yong, K. T., Wang, Y., Roy, I., Rui, H., Swihart, M. T., Law, W.-C., et al. (2012). Preparation of Quantum Dot/Drug Nanoparticle Formulations for Traceable Targeted Delivery and Therapy. Theranostics, 2(7), 681-694.
Series/Report no.: Theranostics
Abstract: Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for in vivo applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases in vitro and in vivo. More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity in vitro and in vivo are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and long-term toxicity, and in vivo applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.
ISSN: 1838-7640
DOI: 10.7150/thno.3692
Rights: © 2012 Ivyspring International Publisher. This paper was published in Theranostics and is made available as an electronic reprint (preprint) with permission of Ivyspring International Publisher. The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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