Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/97945
Title: Nanoparticle based galectin-1 gene silencing, implications in methamphetamine regulation of HIV-1 infection in monocyte derived macrophages
Authors: Nair, Bindukumar B.
Reynolds, Jessica L.
Mahajan, Supriya D.
Sykes, Donald E.
Prasad, Paras N.
Schwartz, Stanley A.
Law, Wing-Cheung
Aalinkeel, Ravikumar
Yong, Ken-Tye
Hui, Rui
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Reynolds, J. L., Law, W.-C., Mahajan, S. D., Aalinkeel, R., Nair, B., Sykes, D. E., et al. (2012). Nanoparticle based galectin-1 gene silencing, implications in methamphetamine regulation of HIV-1 infection in monocyte derived macrophages. Journal of neuroimmune pharmacology, 7(3), 673-685.
Series/Report no.: Journal of neuroimmune pharmacology
Abstract: Galectin-1, an adhesion molecule, is expressed in macrophages and implicated in human immunodeficiency virus (HIV-1) viral adsorption. In this study, we investigated the effects of methamphetamine on galectin-1 production in human monocyte derived macrophages (MDM) and the role of galectin-1 in methamphetamine potentiation of HIV-1 infection. Herein we show that levels of galectin-1 gene and protein expression are significantly increased by methamphetamine. Furthermore, concomitant incubation of MDM with galectin-1 and methamphetamine facilitates HIV-1 infection compared to galectin-1 alone or methamphetamine alone. We utilized a nanotechnology approach that uses gold nanorod (GNR)-galectin-1 siRNA complexes (nanoplexes) to inhibit gene expression for galectin-1. Nanoplexes significantly silenced gene expression for galectin-1 and reversed the effects of methamphetamine on galectin-1 gene expression. Moreover, the effects of methamphetamine on HIV-1 infection were attenuated in the presence of the nanoplex in MDM.
URI: https://hdl.handle.net/10356/97945
http://hdl.handle.net/10220/17054
ISSN: 1557-1890
DOI: 10.1007/s11481-012-9379-7
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

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