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https://hdl.handle.net/10356/98112| Title: | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing | Authors: | Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei |
Keywords: | DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits | Issue Date: | 2014 | Source: | Huang, X., Wang, F., Guo, J., Yan, M., Yu, H., & Yeo, K. S. (2014). A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing. 2014 Symposium on VLSI Circuits Digest of Technical Papers. | Conference: | 2014 Symposium on VLSI Circuits Digest of Technical Papers | Abstract: | A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps. . | URI: | https://hdl.handle.net/10356/98112 http://hdl.handle.net/10220/38537 |
DOI: | 10.1109/VLSIC.2014.6858409 | Schools: | School of Electrical and Electronic Engineering | Rights: | © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [http://dx.doi.org/10.1109/VLSIC.2014.6858409]. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | EEE Conference Papers |
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| A 64×64 1200fps CMOS Ion-Image Sensor.pdf | 860.32 kB | Adobe PDF |  View/Open |
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