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dc.contributor.authorVanDongen, Antonius M. J.en
dc.contributor.authorFu, Yien
dc.contributor.authorChin, Lip Keten
dc.contributor.authorBourouina, Tariken
dc.contributor.authorLiu, Ai Qinen
dc.identifier.citationFu, Y., Chin, L. K., Bourouina, T., Liu, A. Q., & VanDongen, A. M. J. (2012). Nuclear deformation during breast cancer cell transmigration. Lab on a Chip, 12(19), 3774-3778.en
dc.description.abstractMetastasis is the main cause of cancer mortality. During this process, cancer cells dislodge from a primary tumor, enter the circulation and form secondary tumors in distal organs. It is poorly understood how these cells manage to cross the tight syncytium of endothelial cells that lines the capillaries. Such capillary transmigration would require a drastic change in cell shape. We have therefore developed a microfluidic platform to study the transmigration of cancer cells. The device consists of an array of microchannels mimicking the confined spaces encountered. A thin glass coverslip bottom allows high resolution imaging of cell dynamics. We show that nuclear deformation is a critical and rate-limiting step for transmigration of highly metastatic human breast cancer cells. Transmigration was significantly reduced following the treatment with a protein methyltransferase inhibitor, suggesting that chromatin condensation might play an important role. Since transmigration is critical for cancer metastasis, this new platform may be useful for developing improved cancer therapies.en
dc.relation.ispartofseriesLab on a chipen
dc.subjectDRNTU::Science::Medicine::Biomedical engineeringen
dc.titleNuclear deformation during breast cancer cell transmigrationen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
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