Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98259
Title: Structural and functional analysis of multi-interface domains
Authors: Zhao, Liang
Hoi, Steven Chu Hong
Wong, Limsoon
Hamp, Tobias
Li, Jinyan
Keywords: DRNTU::Engineering::Computer science and engineering
Issue Date: 2012
Source: Zhao, L., Hoi, S. C. H., Wong, L., Hamp, T., & Li, J. (2012). Structural and Functional Analysis of Multi-Interface Domains. PLoS ONE, 7(12), e50821.
Series/Report no.: PLoS ONE
Abstract: A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the functions and interfaces as some subsets of the interfaces play the same function. This work applies graph theory and algorithms to discover fingerprints for the multiple interfaces of a domain and to establish associations between the interfaces and functions, based on a huge set of multi-interface proteins from PDB. We found that about 40% of proteins have the multi-interface property, however the involved multi-interface domains account for only a tiny fraction (1.8%) of the total number of domains. The interfaces of these domains are distinguishable in terms of their fingerprints, indicating the functional specificity of the multiple interfaces in a domain. Furthermore, we observed that both cooperative and distinctive structural patterns, which will be useful for protein engineering, exist in the multiple interfaces of a domain.
URI: https://hdl.handle.net/10356/98259
http://hdl.handle.net/10220/10903
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0050821
Rights: © 2012 The Authors. This paper was published in PLoS ONE and is made available as an electronic reprint (preprint) with permission of The Authors. The paper can be found at the following official DOI: [http://dx.doi.org/10.1371/journal.pone.0050821]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCSE Journal Articles

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