Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98436
Title: Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
Authors: Luo, K. Q.
Park, W.
Tsai, J.
Liu, A. Q.
Chin, Lip Ket
Je, Minkyu
Kwong, Dim Lee
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2012
Source: Chin, L. K., Luo, K. Q., Park, W., Je, M., Tsai, J., Kwong, D. L., et al. (2012). Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS).
Abstract: This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.
URI: https://hdl.handle.net/10356/98436
http://hdl.handle.net/10220/12493
DOI: 10.1109/MEMSYS.2012.6170309
Rights: © 2012 IEEE .
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Conference Papers

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