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Title: A study of cancer cell metastasis using microfluidic transmigration device
Authors: Fu, Yi
Bourouina, Tarik
Kwong, Dim Lee
Vandongen, A. M. J.
Park, W. T.
Je, M. Y.
Tsai, J. M.
Liu, A. Q.
Keywords: DRNTU::Engineering::Electrical and electronic engineering
Issue Date: 2012
Source: Fu, Y., Vandongen, A. M. J., Bourouina, T., Park, W. T., Je, M. Y., Tsai, J. M., et al. (2012). A study of cancer cell metastasis using microfluidic transmigration device . 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS).
Abstract: Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm × 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy.
DOI: 10.1109/MEMSYS.2012.6170300
Rights: © 2012 IEEE.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Conference Papers

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