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https://hdl.handle.net/10356/98730
Title: | Magnetic fields facilitate DNA-mediated charge transport | Authors: | Lee, Kee Jin Shu, Jian-Jun Shao, Fangwei Wong, Jiun Ru |
Issue Date: | 2015 | Source: | Wong, J. R., Lee, K. J., Shu, J.-J., & Shao, F. (2015). Magnetic fields facilitate DNA-mediated charge transport. Biochemistry, 54(21), 3392-3399. | Series/Report no.: | Biochemistry | Abstract: | Exaggerated radical-induced DNA damage under magnetic fields is of great concern to medical biosafety and biomolecular electronic devices. In this report, the effects of an external magnetic field (MF) on DNA electronic conductivity were investigated by studying the efficiencies of photoinduced DNA-mediated charge transport (CT) via guanine damage. Under a static MF of 300 mT, positive enhancements in the decomposition of 8-cyclopropyldeoxyguanosine (8CPG) were observed at both the proximal and distal guanine doublets, indicating a more efficient propagation of radical cations and higher electronic conductivity of duplex DNA. MF-assisted CT has shown sensitivity to magnetic field strength, duplex structures, and the integrity of base pair stacking. Spin evolution of charge injection and the alignment of base pairs to the CT-active conformation during radical propagation were proposed to be the two major factors that MF contributes to facilitate DNA-mediated CT. Herein, MF-assisted CT may offer a new avenue for designing DNA-based electronic devices and unraveling MF effects on redox and radical relevant biological processes. | URI: | https://hdl.handle.net/10356/98730 http://hdl.handle.net/10220/38541 |
DOI: | 10.1021/acs.biochem.5b00295 | Schools: | School of Mechanical and Aerospace Engineering School of Physical and Mathematical Sciences |
Rights: | © 2015 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biochemistry, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biochem.5b00295]. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MAE Journal Articles SPMS Journal Articles |
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