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Title: Review of confocal fluorescence endomicroscopy for cancer detection
Authors: Thong, Patricia Soo-Ping
Olivo, Malini
Tandjung, Stephanus Surijadarma
Movania, Muhammad Mobeen
Lin, Feng
Qian, Kemao
Seah, Hock Soon
Soo, Khee-Chee
Keywords: DRNTU::Engineering::Computer science and engineering
Issue Date: 2012
Series/Report no.: IEEE journal of selected topics in quantum electronics
Abstract: The cancer burden is increasing worldwide and there is a need to develop new technologies for cancer diagnosis. Confocal laser endomicroscopy (CLE) is a minimally invasive optical technique that enables in vivo confocal imaging of tissue structures. With the use of fluorescent dyes, the technique allows confocal fluorescence endomicroscopy of tissue from surface to subsurface layers. CLE has been applied to the surveillance and diagnosis of cancer in numerous clinical studies recently, and also holds potential for optical and guided biopsy procedures. The first part of this mini review is focused on the application of CLE for cancer detection and surveillance. The second part is focused on the application of CLE to imaging of the oral cavity. We have previously demonstrated the potential of CLE for diagnostic imaging of oral cavity lesions. To move toward real-time 3-D imaging, we interfaced an endomicroscope to an embedded computing system. The prototype system is capable of automated image acquisition and real-time volume rendering. Rendering results provide topographical and depth information. Our aim is to achieve a real-time 3-D fluorescence imaging system that can be used for diagnostic imaging and guided biopsy procedures of oral cavity lesions in a clinical setting.
ISSN: 1077-260X
DOI: 10.1109/JSTQE.2011.2177447
Rights: © 2011 IEEE
Fulltext Permission: none
Fulltext Availability: No Fulltext
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