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Title: Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study
Authors: Do, Ngoc Quang
Phan, Anh Tuân
Issue Date: 2012
Source: Do, N. Q.,& Phan, A. T. (2012). Monomer-Dimer Equilibrium for the 5′-5′ Stacking of Propeller-Type Parallel-Stranded G-Quadruplexes: NMR Structural Study. Chemistry - A European Journal, 18(46), 14752-14759.
Series/Report no.: Chemistry - a European journal
Abstract: Guanine-rich sequence motifs, which contain tracts of three consecutive guanines connected by single non-guanine nucleotides, are abundant in the human genome and can form a robust G-quadruplex structure with high stability. Herein, by using NMR spectroscopy, we investigate the equilibrium between monomeric and 5′–5′ stacked dimeric propeller-type G-quadruplexes that are formed by DNA sequences containing GGGT motifs. We show that the monomer–dimer equilibrium depends on a number of parameters, including the DNA concentration, DNA flanking sequences, the concentration and type of cations, and the temperature. We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution.
ISSN: 0947-6539
DOI: 10.1002/chem.201103295
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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