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https://hdl.handle.net/10356/99416
Title: | Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study | Authors: | Do, Ngoc Quang Phan, Anh Tuân |
Issue Date: | 2012 | Source: | Do, N. Q.,& Phan, A. T. (2012). Monomer-Dimer Equilibrium for the 5′-5′ Stacking of Propeller-Type Parallel-Stranded G-Quadruplexes: NMR Structural Study. Chemistry - A European Journal, 18(46), 14752-14759. | Series/Report no.: | Chemistry - a European journal | Abstract: | Guanine-rich sequence motifs, which contain tracts of three consecutive guanines connected by single non-guanine nucleotides, are abundant in the human genome and can form a robust G-quadruplex structure with high stability. Herein, by using NMR spectroscopy, we investigate the equilibrium between monomeric and 5′–5′ stacked dimeric propeller-type G-quadruplexes that are formed by DNA sequences containing GGGT motifs. We show that the monomer–dimer equilibrium depends on a number of parameters, including the DNA concentration, DNA flanking sequences, the concentration and type of cations, and the temperature. We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution. | URI: | https://hdl.handle.net/10356/99416 http://hdl.handle.net/10220/12935 |
ISSN: | 0947-6539 | DOI: | 10.1002/chem.201103295 | Schools: | School of Biological Sciences School of Physical and Mathematical Sciences |
Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SBS Journal Articles |
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