[4+2] Annulation of Vinyl Ketones initiated by a Phosphine-Catalyzed Aza-Rauhut-Currier reaction: a practical access to densely functionalized Tetrahydropyridines

Abstract

The first example of phosphine catalyzed aza-Rauhut–Currier reaction initiated [4+2] annulation of vinyl ketones with N-sulfonyl-1-aza-1,3-dienes has been disclosed. Under the ambient conditions, this protocol provides a practical access to valuable densely functionalized tetrahydropyridines in good to excellent yields and high diastereoselectivities (see scheme).