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Title: Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity
Authors: Xiong, Sijing
Tang, Yuxin
Ng, Huiyun Sheena
Zhao, Xinxin
Jiang, Zhelong
Chen, Zhong
Ng, Kee Woei
Loo, Say Chye Joachim
Keywords: DRNTU::Engineering::Materials
Issue Date: 2013
Source: Xiong, S., Tang, Y., Ng, H. S., Zhao, X., Jiang, Z., Chen, Z., Ng, K. W., & Loo, S. C. J. (2013). Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity. Toxicology, 304(8), 132-140.
Series/Report no.: Toxicology
Abstract: The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24 h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects.
ISSN: 0300-483X
DOI: 10.1016/j.tox.2012.12.015
Rights: © 2013 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Toxicology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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