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Title: Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation
Authors: Steele, Terry W. J.
Huang, Charlotte Liwen
Nguyen, Evelyne
Sarig, Udi
Kumar, Saranya
Widjaja, Effendi
Loo, Say Chye Joachim
Machluf, Marcelle
Boey, Freddy Yin Chiang
Vukadinovic, Zlata
Hilfiker, Andreas
Venkatraman, Subbu S.
Keywords: Materials Science and Engineering
Issue Date: 2013
Source: Steele, T. W. J., Huang, C. L., Nguyen, E., Sarig, U., Kumar, S., Widjaja, E., et al. (2013). Collagen–cellulose composite thin films that mimic soft-tissue and allow stem-cell orientation. Journal of materials science : materials in medicine, 24(8), 2013-2027.
Series/Report no.: Journal of materials science : materials in medicine
Abstract: Mechanical properties of collagen films are less than ideal for biomaterial development towards musculoskeletal repair or cardiovascular applications. Herein, we present a collagen–cellulose composite film (CCCF) compared against swine small intestine submucosa in regards to mechanical properties, cell growth, and histological analysis. CCCF was additionally characterized by FE-SEM, NMR, mass spectrometry, and Raman Microscopy to elucidate its physical structure, collagen–cellulose composition, and structure activity relationships. Mechanical properties of the CCCF were tested in both wet and dry environments, with anisotropic stress–strain curves that mimicked soft-tissue. Mesenchymal stem cells, human umbilical vein endothelial cells, and human coronary artery smooth muscle cells were able to proliferate on the collagen films with specific cell orientation. Mesenchymal stem cells had a higher proliferation index and were able to infiltrate CCCF to a higher degree than small intestine submucosa. With the underlying biological properties, we present a collagen–cellulose composite film towards forthcoming biomaterial-related applications.
DOI: 10.1007/s10856-013-4940-3
Fulltext Permission: none
Fulltext Availability: No Fulltext
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