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Title: Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
Authors: Rice, Scott A.
Kardak, Bharat G.
Kelso, Michael J.
Yepuri, Nageshwar Rao
Barraud, Nicolas
Mohammadi, Nasim Shah
Kjelleberg, Staffan
Keywords: Biofilms
Issue Date: 2013
Source: Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., et al. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical communications, 49(42), 4791-4793.
Series/Report no.: Chemical communications
Abstract: Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.
DOI: 10.1039/c3cc40869h
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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