Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/99906| Title: | Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells | Authors: | Choi, Bo-Hwa Kim, Wanil Wang, Qiuxia Chelsia Kim, Dong-Chan Tan, Swee Ngin Yong, Jean Wan Hong Kim, Kyong-Tai Yoon, Ho Sup |
Keywords: | DRNTU::Science::Biological sciences | Issue Date: | 2007 | Source: | Choi, B. -H., Kim, W., Wang, Q. C., Kim, D., -C., Tan, S., N., Yong, J. W. H., et al. (2008). Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Letters, 261(1), 37-45. | Series/Report no.: | Cancer letters | Abstract: | Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway. | URI: | https://hdl.handle.net/10356/99906 http://hdl.handle.net/10220/8384 |
DOI: | 10.1016/j.canlet.2007.11.014 | Schools: | School of Biological Sciences | Rights: | © 2007 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Letters, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.canlet.2007.11.014. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SBS Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 14.Kinetin riboside preferentially induces apoptosis by modulating Bcl.pdf | 395.2 kB | Adobe PDF |  View/Open |
SCOPUSTM
Citations
10
67
Updated on Mar 15, 2025
Web of ScienceTM
Citations
5
62
Updated on Oct 26, 2023
Page view(s) 5
1,065
Updated on Mar 20, 2025
Download(s) 5
827
Updated on Mar 20, 2025
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.