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Title: Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells
Authors: Choi, Bo-Hwa
Kim, Wanil
Wang, Qiuxia Chelsia
Kim, Dong-Chan
Tan, Swee Ngin
Yong, Jean Wan Hong
Kim, Kyong-Tai
Yoon, Ho Sup
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2007
Source: Choi, B. -H., Kim, W., Wang, Q. C., Kim, D., -C., Tan, S., N., Yong, J. W. H., et al. (2008). Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Letters, 261(1), 37-45.
Series/Report no.: Cancer letters
Abstract: Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway.
DOI: 10.1016/j.canlet.2007.11.014
Rights: © 2007 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Letters, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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