Now showing items 1-3 of 3

    • Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation 

      Edupuganti, Raghu Ram; Harikumar, Arigela; Aaronson, Yair; Biran, Alva; Sailaja, Badi Sri; Nissim-Rafinia, Malka; Azad, Gajendra Kumar; Cohen, Malkiel A.; Park, Jung Eun; Shivalila, Chikdu S.; Markoulaki, Styliani; Sze, Siu Kwan; Jaenisch, Rudolf; Meshorer, Eran (2017)
      Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell regulators, we screened a library of endogenously labeled ...
    • Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation 

      Alajem, Adi; Biran, Alva; Harikumar, Arigela; Sailaja, Badi Sri; Aaronson, Yair; Livyatan, Ilana; Nissim-Rafinia, Malka; Sommer, Andreia Gianotti; Mostoslavsky, Gustavo; Gerbasi, Vincent R.; Golden, Daniel E.; Datta, Arnab; Sze, Siu Kwan; Meshorer, Eran (2015)
      Embryonic stem cells (ESCs) possess a distinct chromatin conformation maintained by specialized chromatin proteins. To identify chromatin regulators in ESCs, we developed a simple biochemical assay named D-CAP (differential ...
    • Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells 

      Mattout, Anna; Aaronson, Yair; Sailaja, Badi Sri; Raghu Ram, Edupuganti V.; Harikumar, Arigela; Mallm, Jan-Philipp; Sim, Kae Hwan; Nissim-Rafinia, Malka; Supper, Emmanuelle; Singh, Prim B.; Sze, Siu Kwan; Gasser, Susan M.; Rippe, Karsten; Meshorer, Eran (2015)
      Background: Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures ...