Now showing items 1-3 of 3

    • Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes 

      Chen, Li; Pan, Hong; Tuan, Ta Anh; Teh, Ai Ling; MacIsaac, Julia L.; Mah, Sarah M.; McEwen, Lisa M.; Li, Yue; Chen, Helen; Broekman, Birit F. P.; Buschdorf, Jan Paul; Chong, Yap Seng; Kwek, Kenneth; Saw, Seang Mei; Gluckman, Peter D.; Fortier, Marielle V.; Rifkin-Graboi, Anne; Kobor, Michael S.; Qiu, Anqi; Meaney, Michael J.; Holbrook, Joanna D. (2015)
      Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic ...
    • The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes 

      Teh, Ai Ling; Pan, Hong; Chen, Li; Ong, Mei-Lyn; Dogra, Shaillay; Wong, Johnny; MacIsaac, Julia L.; Mah, Sarah M.; McEwen, Lisa M.; Saw, Seang-Mei; Godfrey, Keith M.; Chong, Yap-Seng; Kwek, Kenneth; Kwoh, Chee-Keong; Soh, Shu-E.; Chong, Mary F. F.; Barton, Sheila; Karnani, Neerja; Cheong, Clara Y.; Buschdorf, Jan Paul; Stünkel, Walter; Kobor, Michael S.; Meaney, Michael J.; Gluckman, Peter D.; Holbrook, Joanna D. (2014)
      Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins ...
    • SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates 

      Shanmugam, Raghuvaran; Zhang, Fan; Srinivasan, Harini; Charles Richard, John Lalith; Liu, Kaiwen I.; Zhang, Xiujun; Woo, Cheok Wei A.; Chua, Zi Hao M.; Buschdorf, Jan Paul; Meaney, Michael J.; Tan, Meng How (2018)
      Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other ...