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    • Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling 

      Nachtergaele, Sigrid; Whalen, Daniel M; Mydock, Laurel K; Zhao, Zhonghua; Malinauskas, Tomas; Krishnan, Kathiresan; Ingham, Philip W; Covey, Douglas F; Siebold, Christian; Rohatgi, Rajat (2013)
      The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the ...