Now showing items 1-2 of 2

    • The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET 

      Ho, James; Sielaff, Hendrik; Nadeem, Aftab; Svanborg, Catharina; Grüber, Gerhard (2015)
      HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study ...
    • Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex 

      Nadeem, Aftab; Sanborn, Jeremy; Gettel, Douglas L.; Ho, James C. S.; Rydström, Anna; Ngassam, Viviane N.; Klausen, Thomas Kjær; Pedersen, Stine Falsig; Lam, Matti; Parikh, Atul N.; Svanbor, Catharina (2015)
      A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This ‘’protein-centric” view is increasingly ...