Now showing items 1-2 of 2

    • Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria 

      Chojnowski, Alexandre; Ong, Peh Fern; Wong, Esther S. M.; Lim, John S. Y.; Mutalif, Rafidah A.; Navasankari, Raju; Dutta, Bamaprasad; Yang, Henry; Liow, Yi Y.; Sze, Siu Kwan; Boudier, Thomas; Wright, Graham D.; Colman, Alan; Burke, Brian; Stewart, Colin L.; Dreesen, Oliver (2015)
      Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and ...
    • The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis 

      Ivanyi-Nagy, Roland; Ahmed, Syed Moiz; Peter, Sabrina; Ramani, Priya Dharshana; Ong, Peh Fern; Dreesen, Oliver; Dröge, Peter (2018)
      Telomerase RNA (TR) provides the template for DNA repeat synthesis at telomeres and is essential for genome stability in continuously dividing cells. We mapped the RNA interactome of human TR (hTR) and identified a set of ...