Now showing items 1-9 of 9

    • Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres 

      Harini, Sriram; Venkatesh, Mayandi; Radhakrishnan, Sridhar; Fazil, Mobashar Hussain Urf Turabe; Goh, Eunice Tze Leng; Rui, Sun; Dhand, Chetna; Ong, Seow Theng; Barathi, Veluchamy Amutha; Beuerman, Roger W.; Ramakrishna, Seeram; Verma, Navin Kumar; Lakshminarayanan, Rajamani (2016)
      Topical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. ...
    • Antimicrobial quaternary ammonium organosilane cross-linked nanofibrous collagen scaffolds for tissue engineering 

      Dhand, Chetna; Balakrishnan, Yamini; Ong, Seow Theng; Dwivedi, Neeraj; Venugopal, Jayarama R.; Harini, Sriram; Leung, Chak Ming; Low, Kenny Zhi Wei; Loh, Xian Jun; Beuerman, Roger W.; Ramakrishna, Seeram; Verma, Navin Kumar; Lakshminarayanan, Rajamani (2018)
      Introduction: In search for cross-linkers with multifunctional characteristics, the present work investigated the utility of quaternary ammonium organosilane (QOS) as a potential cross-linker for electrospun collagen ...
    • Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells 

      Ong, Seow Theng; Chalasani, Madhavi Latha Somaraju; Turabe Fazil, Mobashar Hussain Urf; Prasannan, Praseetha; Kizhakeyil, Atish; Wright, Graham D.; Kelleher, Dermot; Verma, Navin Kumar (2018)
      Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP), also known as AKAP450, is a cytosolic scaffolding protein involved in the targeted positioning of multiple signaling molecules, which are critical ...
    • GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells 

      Fazil, Mobashar Hussain Urf Turabe; Ong, Seow Theng; Chalasani, Madhavi Latha Somaraju; Low, Jian Hui; Kizhakeyil, Atish; Mamidi, Akshay; Lim, Carey Fang Hui; Wright, Graham D.; Lakshminarayanan, Rajamani; Kelleher, Dermot; Verma, Navin Kumar (2016)
      Post-transcriptional gene silencing holds great promise in discovery research for addressing intricate biological questions and as therapeutics. While various gene silencing approaches, such as siRNA and CRISPR-Cas9 ...
    • LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway 

      Verma, Navin Kumar; Mobashar Hussain Urf Turabe Fazil; Ong, Seow Theng; Chalasani, Madhavi Latha Somaraju; Low, Jian Hui; Kottaiswamy, Amuthavalli; Praseetha P; Kizhakeyil, Atish; Kumar, Sunil; Panda, Aditya K.; Freeley, Michael; Smith, Sinead M.; Boehm, Bernhard O.; Kelleher, Dermot (2016)
      In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. LFA-1 stimulation in ...
    • Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer 

      Liow, Sing Shy; Dou, Qingqing; Kai, Dan; Li, Zibiao; Sugiarto, Sigit; Yu, Chris Yee Yung; Kwok, Ryan Tsz Kin; Chen, Xiaohong; Wu, Yun-Long; Ong, Seow Theng; Kizhakeyil, Atish; Verma, Navin Kumar; Tang, Ben Zhong; Loh, Xian Jun (2016)
      A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking ...
    • Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration 

      Ong, Seow Theng; Freeley, Michael; Skubis-Zegadło, Joanna; Fazil, Mobashar Hussain Urf Turabe; Kelleher, Dermot; Fresser, Friedrich; Baier, Gottfried; Verma, Navin Kumar; Long, Aideen (2014)
      Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, ...
    • Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study 

      Ramalingam, Raghavendra; Dhand, Chetna; Leung, Chak Ming; Ezhilarasu, Hariharan; Prasannan, Praseetha; Ong, Seow Theng; Subramanian, Sundarapandian; Mohammed Kamruddin; Lakshminarayanan, Rajamani; Ramakrishna, Seeram; Verma, Navin Kumar; Arunachalam, Kantha Deivi (2019)
      Electrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound ...
    • Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation 

      Chu, Trang T. T.; Sinha, Ameya; Malleret, Benoit; Suwanarusk, Rossarin; Park, Jung Eun; Naidu, Renugah; Das, Rupambika; Dutta, Bamaprasad; Ong, Seow Theng; Verma, Navin Kumar; Chan, Jerry K.; Nosten, François; Rénia, Laurent; Sze, Siu Kwan; Russell, Bruce; Chandramohanadas, Rajesh (2017)
      Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known ...