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    • Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation 

      Davey, Gabriela Elzbieta; Adhireksan, Zenita; Ma, Zhujun; Riedel, Tina; Sharma, Deepti; Padavattan, Sivaraman; Rhodes, Daniela; Ludwig, Alexander; Sandin, Sara; Murray, Benjamin S.; Dyson, Paul J.; Davey, Curtis Alexander (2017)
      The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially ...