Now showing items 1-2 of 2

    • An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1 

      Zheng, Ze; Nayak, Lalitha; Wang, Wei; Yurdagul Jr, Arif; Wang, Xiaobo; Cai, Bishuang; Lapping, Stephanie; Ozcan, Lale; Ramakrishnan, Rajasekhar; Pestell, Richard George; Jain, Mukesh K.; Tabas, Ira (2019)
      Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release ...
    • Dachshund depletion disrupts mammary gland development and diverts the composition of the mammary gland progenitor pool 

      Jiao, Xuanmao; Li, Zhiping; Wang, Min; Katiyar, Sanjay; Di Sante, Gabriele; Farshchian, Mehdi; South, Andrew P.; Cocola, Cinzia; Colombo, Daniele; Reinbold, Rolland; Zucchi, Ileana; Wu, Kongming; Tabas, Ira; Spike, Benjamin T.; Pestell, Richard George (2018)
      DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and ...