Now showing items 1-2 of 2

    • Crystallization studies of the murine c-di-GMP sensor protein STING 

      Su, Yi-Che; Tu, Zhi-Le; Yang, Chao-Yu; Chin, Ko-Hsin; Chuah, Mary Lay-Cheng; Liang, Zhao-Xun; Chou, Shan-Ho (2012)
      The innate immune response is the first defence system against pathogenic microorganisms, and cytosolic detection of pathogen-derived DNA is believed to be one of the major mechanisms of interferon production. Recently, ...
    • Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING 

      Chin, Ko-Hsin; Tu, Zhi-Le; Su, Yi-Che; Yu, Yu-Jen; Chen, Hui-Chen; Lo, Yuan-Chao; Chen, Chin-Pan; Barber, Glen N.; Chuah, Mary Lay-Cheng; Liang, Zhao-Xun; Chou, Shan-Ho (2013)
      The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) ...