Now showing items 1-3 of 3
Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins
The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with ...
A conserved mechanism for binding of p53 DNA-Binding domain and Anti-Apoptotic Bcl-2 family proteins
The molecular interaction between tumor suppressor p53 and the anti-apoptotic Bcl-2 family proteins plays an essential role in the transcription-independent apoptotic pathway of p53. In this study, we investigated the ...
Structural insights into the dual-targeting mechanism of Nutlin-3
Multi-targeting therapy is an emerging strategy of drug discovery to improve therapeutic efficacy, safety and resistance profiles. In this study, we monitored the binding of a potent MDM2 inhibitor Nutlin-3 with anti-apoptotic ...