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Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes
Functional beta cell mass is an essential biomarker for the diagnosis and staging of diabetes. It has however proven technically challenging to study this parameter during diabetes progression. Here we have detailed the ...
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
Insulin resistance and β-cell failure are the major defects in type 2 diabetes mellitus. However, the molecular mechanisms linking these two defects remain unknown. Elevated levels of apolipoprotein CIII (apoCIII) are ...