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Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506
The emergence of multi-drug-resistant strains of Plasmodium parasites has prompted the search for alternative therapeutic strategies for combating malaria. One possible strategy is to exploit existing drugs as lead compounds. ...
Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide
Plasmodium falciparum FK506-binding protein 35 (PfFKBP35) that binds to FK506 contains a conserved tetratricopeptide repeat (TPR) domain. Several known TPR domains such as Hop, PPP5, CHIP, and FKBP52 are structurally ...
NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax
PvFKBP35 is a member of the FK506 binding protein family (FKBP) from Plasmodium vivax. The FK506- binding domain of PvFKBP35 shows a canonical peptidylprolyl cis–trans isomerase ...