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Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

Ba, Sai; Zhang, Hao; Lee, Jasmine Yiqin; Wu, Haixia; Ye, Ruijuan; Huang, Dejian; Li, Tianhu (2016)

Flap structure-specific endonuclease 1 (FEN1) is one of the enzymes that involve in Eukaryotic DNA replication and repair. Recent studies have proved that FEN1 is highly over-expressed in various types of cancer cells and ...