Now showing items 1-10 of 28
Molecular basis of Bcl-XL-p53 interaction : insights from molecular dynamics simulations
Bcl-XL, an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apoptotic pathway. Heterodimerization of the antiapoptotic Bcl-2 family proteins with the proapoptotic family members such as ...
Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells
The present study reports the design and synthesis of nine C2-symmetric 5,15-[bis(arayl)]-10α,20β- [bis(1,2:3,4-di-O-isopropylidene-α-D-galactopyranose-6-yl)]porphyrins (3–11) bearing electron donating or electron ...
Targeting FK506 binding proteins to fight malarial and bacterial infections : current advances and future perspectives
There is an urgent need for the design and development of new and selective drugs for the treatment of malaria and bacterial infections as these pathogens are developing resistance to presently available therapies. Malaria ...
The NS5A domain II of HCV : conservation of intrinsic disorder in several genotypes
Abstract unavailable in full text.
FKBP38 protects Bcl-2 from caspase-dependent degradation
The cellular processes that regulate Bcl-2 at the posttranslational levels are as important as those that regulate bcl-2 synthesis. Previously we demonstrated that the suppression of FK506-binding protein 38 (FKBP38) ...
NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35
The emergence of drug-resistant malaria parasites is the major threat to effective malaria control, prompting a search for novel compounds with mechanisms of action that are different from the traditionally used drugs. The ...
Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins
The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with ...
The natively disordered loop of Bcl-2 undergoes phosphorylation-dependent conformational change and interacts with Pin1
Bcl-2 plays a central role in the regulation of apoptosis. Structural studies of Bcl-2 revealed the presence of a flexible and natively disordered loop that bridges the Bcl-2 homology motifs, BH3 and BH4. This loop is ...
Molecular diversity and function of jasmintides from Jasminum sambac
Background: Jasmintides jS1 and jS2 from Jasminum sambac were previously identified as a novel family of cysteine-rich peptides (CRPs) with an unusual disulfide connectivity. However, very little else is known about ...
Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin
The nuclear immunophilin FKBP25 interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids. Currently the structural basis of nucleic acid binding by FKBP25 is ...