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The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-XL-binding motif
While the transcription-dependent mechanism of p53 has been extensively studied, recently the transcription-independent apoptotic activity of p53 has also been described. Bcl-2 and Bcl-XL interact with p53 and induce ...
Design of β-hairpin peptides for modulation of cell adhesion by β-turn constraint
The CD2−CD58 interaction in immune regulation and disease pathology has provided new targets for developing potential immunosuppressive agents. In the present study, we report the introduction of constraints to generate ...
Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide
Plasmodium falciparum FK506-binding protein 35 (PfFKBP35) that binds to FK506 contains a conserved tetratricopeptide repeat (TPR) domain. Several known TPR domains such as Hop, PPP5, CHIP, and FKBP52 are structurally ...
NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax
PvFKBP35 is a member of the FK506 binding protein family (FKBP) from Plasmodium vivax. The FK506- binding domain of PvFKBP35 shows a canonical peptidylprolyl cis–trans isomerase ...