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Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor
Shc is a widely expressed adapter protein that plays an important role in signaling via a variety of cell surface receptors and has been implicated in coupling the stimulation of growth factor, cytokine, and antigen receptors ...
Structural characterization of the interaction between a Pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate
The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids that is found in several proteins involved in signal transduction [for a recent review, see Gibson et al. (1994) Trends Biochem. ...
Subsets close to invariant subsets for group actions
Let G be a group acting on a set Ω and k a non-negative integer. A subset (finite or infinite) A ⊆ Ω is called k-quasi-invariant if |Ag \ A| ≤k for every g ∈ G. It is shown that if A is k-quasi-invariant for k ≥1 , then ...
Shimura subgroups and degeneracy maps
For M ≥ 1 an integer and M′ a positive divisor of M, let φ: J0(M′)τ → J0(M) be the map defined by all the degeneracy maps, where τ is the number of positive divisors of M/M′. We determine the kernel of φ for certain M and ...