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Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of ...
DNA damage regulation and its role in drug-related phenotypes in the malaria parasites
DNA of malaria parasites, Plasmodium falciparum, is subjected to extraordinary high levels of genotoxic insults during its complex life cycle within both the mosquito and human host. Accordingly, most of the components of ...